abstract：:Melatonin and somatostatin are known to exert similar effects on locomotor activity. We have previously demonstrated that acute melatonin treatment regulates somatostatin receptor function in the rat frontoparietal cortex. However, the effects of subchronic and chronic melatonin treatment on the somatostatin receptor-...

journal_title：Journal of pineal research

authors： Izquierdo-Claros RM,Boyano-Adánez Mdel C,Arilla-Ferreiro E

更新日期：2002-11-01 00:00:00

abstract：:The effect of melatonin (0.1 microM) on freshly isolated islets from adult rats was investigated. Melatonin caused a marked decrease of insulin secretion by islets in response to glucose. The mechanism involved was then examined. Melatonin did not interfere with glucose metabolism as indicated by the measurement of gl...

journal_title：Journal of pineal research

authors： Picinato MC,Haber EP,Cipolla-Neto J,Curi R,de Oliveira Carvalho CR,Carpinelli AR

更新日期：2002-10-01 00:00:00

abstract：:The production of oxygen free radicals has been strongly implicated as an important pathophysiological mechanism mediating myocardial ischemia/reperfusion (I/R) injury. Various antioxidants have cardioprotective effects. Melatonin, an indoleamine synthesized by the pineal gland, is a potent antioxidant and a direct fr...

journal_title：Journal of pineal research

authors： Lee YM,Chen HR,Hsiao G,Sheu JR,Wang JJ,Yen MH

更新日期：2002-09-01 00:00:00

abstract：:Melatonin, the major secretory product of the pineal gland, is in focus of many research areas because of its ability to scavenge free oxygen radicals and thereby protect cells and tissues from radical damage. Some studies suggest melatonin may be a possible therapeutic agent with potential clinical applications again...

journal_title：Journal of pineal research

authors： Hermann R,Podhajsky S,Jungnickel S,Lerchl A

更新日期：2002-08-01 00:00:00

abstract：:The objective of this study was to determine the role of alpha-adrenoceptors in melatonin production by rat pineal gland. Pineal glands were isolated from adult male rats and maintained in organ baths. The perfusate was sampled every 5 min, stored, and later assayed for melatonin. Exposure to norepinephrine (10 microM...

journal_title：Journal of pineal research

authors： Tobin VA,McCance I,Coleman HA,Parkington HC

更新日期：2002-05-01 00:00:00

abstract：:Melatonin is a potent scavenger of free radicals and an indirect antioxidant. Recent studies have shown that melatonin possesses beneficial effects in experimental models of brain trauma and global cerebral ischemia. The effects of pretreatment with melatonin on volume of cerebral infarction were investigated in the p...

journal_title：Journal of pineal research

authors： Pei Z,Pang SF,Cheung RT

更新日期：2002-04-01 00:00:00

abstract：:Excessive production of nitric oxide (NO) may play a detrimental role in the process of hypoxia-related neuropathology. This study explored whether treatment with melatonin would attenuate the neuropathological changes in the vagal ganglia following a severe hypoxic insult. Thirty minutes prior to hypoxia treatment, y...

journal_title：Journal of pineal research

authors： Chang HM,Ling EA,Chen CF,Lue H,Wen CY,Shieh JY

更新日期：2002-03-01 00:00:00

abstract：:A decrease in nocturnal serum melatonin levels was reported in patients with clinically uncharacterized coronary artery disease. To assess whether there was a correlation between melatonin production and disease stage, we measured the nocturnal urinary excretion of 6-sulphatoxymelatonin (an index of blood melatonin co...

journal_title：Journal of pineal research

authors： Girotti L,Lago M,Ianovsky O,Carbajales J,Elizari MV,Brusco LI,Cardinali DP

更新日期：2000-10-01 00:00:00

abstract：:There is substantial evidence that magnetic field (MF) exposure influences melatonin secretion in animals. However, data on its influence on human melatonin levels are scarce, and seemingly contradictory. Because of its many beneficial effects, very low-frequency MF exposure is used in physiotherapy of some neurologic...

journal_title：Journal of pineal research

authors： Karasek M,Czernicki J,Woldanska-Okonska M,Zylinska K,Swietoslawski J

更新日期：2000-09-01 00:00:00

abstract：:An interaction between melatonin and adrenocorticotropin (ACTH) seems to occur in humans and both hormones respond to beta-adrenergic stimulation. As in lower animal species, human pineal gland also contains alpha2-adrenergic receptors as does the hypothalamus-pituitary axis. In this study the response of the pineal g...

journal_title：Journal of pineal research

authors： Muñóz-Hoyos A,Fernández-García JM,Molina-Carballo A,Macías M,Escames G,Ruiz-Cosano C,Acuña-Castroviejo D

更新日期：2000-08-01 00:00:00

abstract：:Melatonin displays antioxidant and free radical scavenger properties. Due to its ability with which it enters cells, these protective effects are manifested in all subcellular compartments. Recent studies suggest a role for melatonin in mitochondrial metabolism. To study the effects of melatonin on this organelle we u...

journal_title：Journal of pineal research

authors： Martín M,Macías M,Escames G,Reiter RJ,Agapito MT,Ortiz GG,Acuña-Castroviejo D

更新日期：2000-05-01 00:00:00

abstract：:In the present research, we studied the effect of the administration of melatonin or S-adenosyl-L-methionine (S-AMe) on oxidative stress and hepatic cholestasis produced by double ligature of the extra-hepatic biliary duct (LBD) in adult male Wistar rats. Hepatic oxidative stress was evaluated by the changes in the am...

journal_title：Journal of pineal research

authors： López PM,Fiñana IT,De Agueda MC,Sánchez EC,Muñoz MC,Alvarez JP,De La Torre Lozano EJ

更新日期：2000-04-01 00:00:00

abstract：:Melatonin is a powerful scavenger of oxygen free radicals. In humans, melatonin is rapidly transferred from the maternal to the fetal circulation. To investigate whether or not maternal melatonin administration can protect the fetal rat brain from radical-induced damage by increasing the activities of antioxidant enzy...

journal_title：Journal of pineal research

authors： Okatani Y,Wakatsuki A,Kaneda C

更新日期：2000-03-01 00:00:00

abstract：:We evaluated the feasibility of using morning urine samples in epidemiological studies aimed at clarifying the relationship between nocturnal melatonin levels and breast cancer risk. Initially, a laboratory-based study of 29 women (40- 70 yr old) was performed to examine the correlation between plasma melatonin levels...

journal_title：Journal of pineal research

authors： Cook MR,Graham C,Kavet R,Stevens RG,Davis S,Kheifets L

更新日期：2000-01-01 00:00:00

abstract：:Most contemporary progress in Alzheimer's disease (AD) stems from the study of a 42 43 amino acid peptide. called the amyloid beta protein (Abeta), as the main neuropathologic marker of the disorder. It has been demonstrated that Abeta has neurotoxic properties and that such effects are mediated by free-radicals. Expo...

journal_title：Journal of pineal research

authors： Pappolla MA,Chyan YJ,Poeggeler B,Bozner P,Ghiso J,LeDoux SP,Wilson GL

更新日期：1999-11-01 00:00:00

abstract：:The effect of melatonin injection on Freund's adjuvant-induced changes in levels and 24-hr rhythms of circulating ACTH, growth hormone (GH), prolactin (PRL), luteinizing hormone (LH), and insulin was assessed in rats. Animals received subcutaneous (s.c.) injections of melatonin (30 microg) or vehicle, 1 hr before ligh...

journal_title：Journal of pineal research

authors： Esquifino AI,Castrillón P,García-Bonacho M,Vara E,Cardinali DP

更新日期：1999-08-01 00:00:00

abstract：:Thrombocytopenia is a frequent complication of cancer and constitutes an absolute contraindication for chemotherapy. Recent studies have demonstrated that platelet generation may be influenced by both cytokines and neurohormones. In particular, the pineal indole melatonin has been proven to enhance platelet number in ...

journal_title：Journal of pineal research

authors： Lissoni P,Tancini G,Paolorossi F,Mandalà M,Ardizzoia A,Malugani F,Giani L,Barni S

更新日期：1999-04-01 00:00:00

abstract：:The pineal hormone melatonin, due to its lipophilic nature, has access to every cell and every part of a cell in the body, suggesting that it could exert effects on blood immune cells. The regulation of the activation of monocytes may be important in a number of diseases, especially pathophysiological conditions assoc...

journal_title：Journal of pineal research

authors： Fjaerli O,Lund T,Osterud B

更新日期：1999-01-01 00:00:00

abstract：:The pineal hormone melatonin has been reported to have in vitro antiproliferative effects on estrogen receptor-positive human breast cancer cell lines at concentrations near to plasma physiological concentrations (1 x 10(-11) to 1 x 10(-9) M). Its growth inhibitory actions have been thought to be linked to the estroge...

journal_title：Journal of pineal research

authors： Papazisis KT,Kouretas D,Geromichalos GD,Sivridis E,Tsekreli OK,Dimitriadis KA,Kortsaris AH

更新日期：1998-12-01 00:00:00

abstract：:Our objective was to evaluate the maternal-fetal transfer of melatonin in pregnant women. Serum melatonin concentration was measured by high-performance liquid chromatography with electrochemical detection in a maternal vein and in the umbilical artery and umbilical vein at the time of birth. Blood samples were obtain...

journal_title：Journal of pineal research

authors： Okatani Y,Okamoto K,Hayashi K,Wakatsuki A,Tamura S,Sagara Y

更新日期：1998-10-01 00:00:00

abstract：:We have studied the effect of the administration of two doses of melatonin (melatonin 100 and melatonin 200 microg/kg bw) on diabetes and oxidative stress experimentally induced by the injection of streptozotocin (STZ) in female Wistar rats. STZ was injected as a single dose (60 mg/kg i.p. in buffered citrate solution...

journal_title：Journal of pineal research

authors： Montilla PL,Vargas JF,Túnez IF,Muñoz de Agueda MC,Valdelvira ME,Cabrera ES

更新日期：1998-09-01 00:00:00

abstract：:By use of Phaseolus vulgaris-leucoagglutinin as an anterograde in vivo tracer, a direct projection from the dorsal raphe nucleus to the pineal complex of the rat was demonstrated. The nerve fibers extended from the dorsal raphe nucleus rostrally through the mesencephalic periaqueductal grey and entered the deep pineal...

journal_title：Journal of pineal research

authors： Møller M,Hay-Schmidt A

更新日期：1998-08-01 00:00:00

abstract：:Melatonin was tested in an ongoing attempt to find the endogenous antagonists of quinolinic acid, an endogenous convulsant. Among a great number of metabolites that have been tried before, only a few were found (cerulein and quinaldic acid in mice and kynurenic acid in rats). In SHR (bred from Swiss) male mice, intrac...

journal_title：Journal of pineal research

authors： Lapin IP,Mirzaev SM,Ryzov IV,Oxenkrug GF

更新日期：1998-05-01 00:00:00

abstract：:We examined the association between 6-sulphatoxymelatonin (6-SMT) excretion and sleep in 68 volunteers 60-79 years of age who complained of insomnia or depression. An Actillume wrist monitor was worn for 5-7 consecutive days and nights in home-living conditions. Activity was used to estimate total sleep time (TST) and...

journal_title：Journal of pineal research

authors： Youngstedt SD,Kripke DF,Elliott JA

更新日期：1998-04-01 00:00:00

abstract：:The effect of melatonin administration on nerve growth factor (NGF) was studied in the submandibular glands of adult Swiss male mice. Melatonin injection, at 1 microg daily for 30 days, resulted in an increase in the NGF content as detected by immunohistochemistry. The submandibular gland weight and the area of the gr...

journal_title：Journal of pineal research

authors： Pongsa-Asawapaiboon A,Asavaritikrai P,Withyachumnarnkul B,Sumridthong A

更新日期：1998-03-01 00:00:00

abstract：:Four weeks of administration of melatonin mixed in the diet (5 mg/kg of food) significantly reduced the incidence of gastric ulcers in young pigs. In control and melatonin supplemented animals, significantly higher levels of melatonin were found in the stomach tissues as compared to jejunum, ileum, or colon. Pigs with...

journal_title：Journal of pineal research

authors： Bubenik GA,Ayles HL,Friendship RM,Brown GM,Ball RO

更新日期：1998-01-01 00:00:00

abstract：:Lethal oxidative stress was investigated in the dinoflagellate Gonyaulax polyedra by measuring the dying-peak of bioluminescence during circadian phases of low physiological light emission, low bioluminescence capacity, and low sensitivity to stimulatory agents. Measurements were carried out in constant darkness after...

journal_title：Journal of pineal research

authors： Antolín I,Obst B,Burkhardt S,Hardeland R

更新日期：1997-11-01 00:00:00

abstract：:The cellular proliferative activity in the adult rat pineal gland was studied using bromodeoxyuridine immunohistochemistry during the light and dark phases of an artificial 12L:12D photoperiod. The results showed statistically significant differences in the number of labeled cells between the light and dark phases, wi...

journal_title：Journal of pineal research

authors： Calvo JL,Boya J,Carbonell AL,García-Mauriño JE

更新日期：1997-08-01 00:00:00

abstract：:We evaluated the antioxidant property of melatonin as it relates to the vasospastic effect of hydrogen peroxide (H2O2) on the human umbilical artery. Helical sections of umbilical arteries were obtained from healthy pregnant women who were delivered between weeks 37 and 39 of gestation. Changes in maximal potassium ch...

journal_title：Journal of pineal research

authors： Okatani Y,Watanabe K,Hayashi K,Wakatsuki A,Sagara Y

更新日期：1997-04-01 00:00:00

abstract：:The oncostatic effects of melatonin on the mammary gland have been studied in transgenic mice carrying the N-ras proto-oncogene under the control of the MMTV-LTR. Female (4-week-old) virgin mice with positive transgenic pedigrees were injected with melatonin (200 micrograms/mouse/ day, five times a week) or vehicle la...

journal_title：Journal of pineal research

authors： Mediavilla MD,Güezmez A,Ramos S,Kothari L,Garijo F,Sánchez Barceló EJ

更新日期：1997-03-01 00:00:00

abstract：:A review of the literature indicates that the absolute oral bioavailability of exogenous melatonin in humans or in preclinical animal models has not been adequately characterized; hence, this study was undertaken. Pharmacokinetics of melatonin was studied in rats, dogs, and monkeys following intravenous and oral admin...

journal_title：Journal of pineal research

authors： Yeleswaram K,McLaughlin LG,Knipe JO,Schabdach D

更新日期：1997-01-01 00:00:00

abstract：:Previous data have demonstrated that a single 1-hr light pulse at night affects the secretion of melatonin in the ram if it was given at the appropriate time. This paper reports the effect on melatonin secretion of a 1-hr light pulse given at two different times at night to two groups of rams kept in constant darkness...

journal_title：Journal of pineal research

authors： Ravault JP,Chesneau D

更新日期：1996-11-01 00:00:00

abstract：:The aim of the study was to determine whether a discrepancy between the genetically determined endogenous circadian period and an abnormally long Zeitgeber period disturbs the development of melatonin synthesis. Breeding pairs of rats were kept under 12:12- or 14:14-hr light:dark (LD) conditions. Pineal melatonin cont...

journal_title：Journal of pineal research

authors： Laakso ML,Alila A,Hätönen T,Mustanoja SM

更新日期：1996-10-01 00:00:00

abstract：:The effect on nocturnal melatonin secretion of acute administration of the indirectly acting serotonin (5-HT) receptor agonists d-fenfluramine (30 mg) and paroxetine (20 mg) and a partial 5-HT1A receptor agonist ipsapirone (20 mg) was investigated in healthy male volunteers and compared to a placebo condition. Each su...

journal_title：Journal of pineal research

authors： Nathan PJ,Norman TR,Burrows GD

更新日期：1996-09-01 00:00:00

abstract：:The effects of noradrenergic and cholinergic receptor agonists on intracellular Ca2+ concentration ([Ca2+]i) in single dissociated rat pineal cells were investigated by microfluorimetric measurements in Fura-2 acetoxymethyl ester (Fura-2/AM) loaded cells. Noradrenaline (NA) evoked characteristic biphasic increments of...

journal_title：Journal of pineal research

authors： Marín A,Ureña J,Tabares L

更新日期：1996-08-01 00:00:00

abstract：:The pineal gland of poikilothermic vertebrates originates as an evagination from the diencephalic roof between the habenular and the posterior commissures, and associates with a parapineal organ to form the so-called pineal complex. The pinealocytes may be photosensitive, secretory or intermediate cells between both. ...

journal_title：Journal of pineal research

authors： Filadelfi AM,Castrucci AM

更新日期：1996-05-01 00:00:00

abstract：:Production of melatonin in the pineal gland of inbred mice such as C57B1/6J, BALB/c and AKR strains is still a matter of debate. In previous studies, we and other authors showed that these strains of inbred mice have a clear-cut circadian rhythm of serum melatonin and urinary 6-hydroxy-melatonin-sulphate. In contrast,...

journal_title：Journal of pineal research

authors： Conti A,Maestroni GJ

更新日期：1996-04-01 00:00:00

abstract：:To examine the role of melatonin in pathological hyperprolactinemia we compared untreated young females (N = 5) with hyperprolactinemic amenorrhea owing to pituitary microadenoma to healthy female controls (N = 6). Serum samples for melatonin, prolactin, and luteinizing hormone (LH) concentrations were obtained every ...

journal_title：Journal of pineal research

authors： Luboshitzky R,Lavi S,Thuma I,Lavie P

更新日期：1996-03-01 00:00:00

abstract：:Melatonin binding sites were characterized in rat spleen crude membranes. The specific binding of 2-[125I]iodomelatonin by spleen crude membranes fulfills all the criteria for binding to a receptor site. Thus, binding was dependent on time and temperature, stable, specific, and increased under constant light exposure ...

journal_title：Journal of pineal research

authors： Rafii-El-Idrissi M,Calvo JR,Giordano M,Guerrero JM

更新日期：1996-01-01 00:00:00

abstract：:Melatonin is an excellent free radical scavenger, reacting with tert-butoxyl and cumyloxyl radicals with rate constants of 3.4 x 10(7) and 6.7 x 10(7) M-1s-1, respectively. Reaction with benzophenone triplet occurs with a near-diffusion-controlled rate constant of 7.6 x 10(9) M-1s-1 in acetonitrile and probably involv...

journal_title：Journal of pineal research

authors： Scaiano JC

更新日期：1995-11-01 00:00:00